- Title
- A comparison of single-photon emission CT lung scintigraphy and CT pulmonary angiography for the diagnosis of pulmonary embolism
- Creator
- Miles, Susan; Rogers, Kerry M.; Thomas, Paul; Soans, Barry; Attia, John; Abel, Christian; Holt, Elizabeth; D'Este, Catherine A.; Hensley, Michael J.
- Relation
- Chest Vol. 136, Issue 6, p. 1546-1553
- Publisher Link
- http://dx.doi.org/10.1378/chest.09-0361
- Publisher
- American College of Chest Physicians
- Resource Type
- journal article
- Date
- 2009
- Description
- Background: This study compared single-photon emission CT (SPECT) ventilation/perfusion (V/Q) scintigraphy with multislice CT pulmonary angiography (CTPA). Methods: In a prospective, observational study, 100 patients who were ≥ 50 years of age were recruited. Seventy-nine patients underwent both diagnostic 16-detector CTPA, and planar and SPECT V/Q scintigraphy. The agreement between the CTPA and the SPECT V/Q scintigraphy for the diagnosis of pulmonary embolism (PE) was calculated. The sensitivity and specificity of blinded SPECT scintigraphy reporting was calculated against a reference diagnosis made by a panel of respiratory physicians that was provided with CTPA and planar V/Q scintigraphy reports, clinical information, and 3-month follow-up data. Results: The observed percentage of agreement between SPECT V/Q scintigraphy and CTPA data for the diagnosis of PE was 95%. When calculated against the respiratory physicians’ reference diagnosis, SPECT V/Q scintigraphy had a sensitivity of 83% and a specificity of 98%. Conclusions: This study indicates that SPECT V/Q scintigraphy is a viable alternative to CTPA for the diagnosis of PE and has potential advantages in that it was feasible in more patients and had fewer contraindications; lower radiation dose; and, arguably, fewer nondiagnostic findings than CTPA. Abbreviations: CTPA = CT pulmonary angiography; PE = pulmonary embolism; PIOPED = Prospective Investigation of Pulmonary Embolism Diagnosis; SPECT = single-photon emission CT; V/Q = ventilation/perfusion.
- Subject
- ventilation perfusion scintigraphy; computed tomography; radiation; probability; outpatients
- Identifier
- uon:7370
- Identifier
- http://hdl.handle.net/1959.13/807318
- Identifier
- ISSN:0012-3692
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